Animal Health Human Health #OneHealth: The Life and Legacy of Dr. James H. Steele

Animal Health Human Health #OneHealth: The Life and Legacy of Dr. James H. Steele

Animal Health Human Health #OneHealth: The Life and Legacy of Dr. James H. Steele

james-steele1“To call Jim Steele “just” a veterinarian is like saying Bill Gates is “just” a software engineer. During his one hundred years of life, Steele changed the face of veterinary medicine and public health.

As the first US assistant surgeon general for veterinary affairs at the Centers for Disease Control in Atlanta, he pioneered the simple but powerful philosophy that human health is intimately connected to the health of animals and our surrounding environment. His unwavering convictions, passion for medical progress, and strong leadership have saved and enriched countless human and animal lives. Animal Health Human Health One Health recounts Jim Steele’s remarkable story, bringing to life his rough-and-tumble childhood in Chicago, his veterinary and academic career, countless battles with deadly diseases, public health adventures around the globe, creation of the first comprehensive scientific book series on zoonotic diseases, and his final years when he was still speaking, coauthoring scientific articles and books, and mentoring and advising students, colleagues and world leaders. He was the father of Veterinary Public Health and a motivator to all who met him.

His life story is a great inspiration for anyone with curiosity and passion for the health, life and environmental sciences.”

Get the book via Amazon at: http://www.amazon.com/Animal-Health-Human-One-Legacy/dp/1511558016

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The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research

The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research

The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research

Recently, there has been renewed interest in comparative oncology— the study of naturally developing cancers in animals as models for human disease—as one way to improve cancer drug development and reduce attrition of investigational agents.

Purebred Golden Retriever dog outdoors on a sunny summer day.

Purebred Golden Retriever dog outdoors on a sunny summer day.

Tumors that spontaneously develop in pet dogs and other companion animals as a result of normal aging share many characteristics with human cancers, such as histological appearance, tumor genetics, biological behavior, molecular targets, and therapeutic response. They also exhibit acquired resistance, recurrence, and metastasis, similar to human cancers.

The Comparative Oncology Trials Consortium was established to provide the infrastructure and resources needed to integrate clinical trials for pets with naturally occurring cancers into the development pathways for new drugs, devices, and imaging techniques for human cancers. However, the cancer research community has not reached agreement concerning the value of these clinical trial data for advancing human cancer research or when and how best to integrate comparative oncology trials within the cancer research continuum. Thus, the Institute of Medicine’s National Cancer Policy Forum, with support from a coalition of sponsors, hosted a workshop held in Washington, DC, on June 8–9, 2015, to examine the rationale and potential for integrating clinical trials for pet patients with naturally occurring cancers into translational cancer research and development. The workshop also highlighted potential opportunities to overcome existing challenges to that integration.

The workshop also reviewed the role of “One Health” in comparative oncology, see below:

The “one medicine” concept is a core principle underpinning the inclusion of clinical trials for pet animals in the cancer research continuum, said Matthew Breen from North Carolina State University. The idea behind “one medicine” is that collaboration among multiple disciplines in animal and human health can contribute to producing the optimal health for both. The mouse is the traditional preclinical research model for cancer, but the induced or transplanted tumors studied in mice are not naturally occurring. Additionally, many preclinical cancer studies are conducted in immunoincompetent mice, while spontaneous canine tumors occur in animals with intact immune systems, making them more similar to human cancers.

The types of cancers that affect people also naturally occur in pets, so knowledge gained from clinical trials for pet patients with spontaneous tumors can complement the traditional approach to preclinical cancer research prior to conducting trials for human patients. In particular, Breen said, certain dog breeds are highly affected by certain naturally occurring cancers, and this suggests that dog breeds have an inherited predisposition to those cancers. The fact that canine cancers show some breed predispositions provides a powerful research opportunity to identify the genetic factors that underlie these predispositions in dogs and simultaneously to contribute to advancing cancer research in humans. Additionally, these naturally occurring cancers develop in the same environment as those in humans.

Visit the website and read the full workshop report at: http://iom.nationalacademies.org/Reports/2015/The-Role-of-Clinical-Studies-Pets-Naturally-Occurring-Tumors-Transitional-Cancer-Research.aspx

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Scientists urged to break the thought silos

Scientists urged to break the thought silos

Scientists urged to break the thought silos

Crossing disciplinary boundaries is unusual – and crucially important. In 1998, groundbreaking thinker and eminent biologist EO Wilson cautioned against scientific overspecialization, warning that thought silos “…must be torn down in order for humanity to progress.” Sociobiologist Rebecca Costa argued in 2010 that “the more fortified and numerous silos become, the further away humankind strays from a unified, systemic approach to our greatest threats.”

The big problems we face today demand interdisciplinary innovation. Look no further than the international climate talks in Paris for an example of an issue that must be approached by individuals with deep disciplinary expertise but also from an interdisciplinary perspective. Big ideas come from understanding the big picture and making cross-boundary connections, not only from eking out incremental advances in an esoteric subfield.

Not surprisingly, universities, research organizations and funding agencies of all stripes – keenly aware of the enormous potential of cross-disciplinary collaboration – enthusiastically tout their support for all things interdisciplinary. Think of nanotechnology, which draws on physics, biology and chemistry. Or disease control efforts that rely on public health officials, behavioral scientists, biostatisticians and epidemiologists.

Deep and broad research approaches both have advantages and disadvantages. So why do people in different scientific specialties so rarely engage in meaningful collaborative projects? My collaborator Andrew Hess and I recently investigated scientists’ goals and work styles with an eye toward the depth versus breadth of their research output.

What do funders value in grant proposals? Ohio Sea Grant, CC BY-NC

What do funders value in grant proposals? Ohio Sea Grant, CC BY-NC

Sure it’s structural, but people can choose

Amidst the calls for boundary-spanning collaboration, the fact is that most scientists work within institutional and professional contexts that overwhelmingly favor and reward deep specialization. Consider the names of departments and journals, how communications flow within rather than across unit boundaries, and how pay and grant monies are allocated. For some, the word“generalist” is pejorative, but collaborating across disciplines does not need to be a bad thing. In fact, in one survey of faculty, 70% agreed with the value of cross-disciplinary work.

Beyond structural determinants, what are the personal drivers that shape the depth versus breadth of researchers’ professional output? While investigating this question, Andrew Hess and I defined deep research as that which adds to our knowledge in highly specialized ways. We defined broad research as that which spans a greater variety of topics.

How much impact can research have if it’s just an incremental advance in a super-specific discipline? US Army Africa, CC BY

How much impact can research have if it’s just an incremental advance in a super-specific discipline? US Army Africa, CC BY

How our researchers rated depth versus breadth

In our first study, we provided medical researchers with descriptions of two hypothetical studies. One was deeply specialized; the other was broad and boundary-spanning. Both had relevance to the participants’ expertise, and we said they were fully funded. We asked them to rate the attractiveness of the two studies along dimensions including risk, significance of opportunity, potential importance and so on.

The results were clear: all else being equal, the broader study was seen as representing a riskier and less significant opportunity, of lower potential import. Respondents were less likely to follow up on the interdisciplinary research. Forced to choose, two-thirds of the researchers said they’d pursue the deeper over the broader study.

Fundamentally, these scientists saw boundary-crossing research as offering high levels of professional risk with low rewards and only meager professional returns.

Output reflects mindset

In the next study, we collected questionnaire data from 466 medical researchers about their goals and outlooks. Then we compared their responses with archival data that allowed us to objectively assess the depth and breadth of their 10-year publication portfolios. The questionnaires provided useful insights into key work-related behaviors and attitudes, including such traits as competitiveness and conscientiousness.

We were able to relate the researchers’ behaviors and mindsets, as reflected in their questionnaire scores, to the breadth and depth of their published research. It turned out that researchers’ goalspredicted the depth versus the breadth of their publication portfolios.

Researchers who were strongly motivated to demonstrate high performance (performance goal orientation) exhibited more depth over a decade of research, but not more breadth. The opposite – more breadth, and not more depth – held for those who reported great interest in trying and learning new things, even if doing so would prove costly in terms of time and professional advancement (high learning goal orientation).

This finding makes sense when you consider that performance is often judged by publications in highly specialized journals that advance knowledge in a researcher’s specific subfield. One would have to be driven to learn new things, perhaps at significant cost, in order to willingly buck the expectation and go for a broader approach that isn’t often rewarded. Research doesn’t happen by structural fiat; it’s also driven by what the individual scientist finds intrinsically appealing and rewarding.

Our scientist participants also differed in the extent to which they focused their efforts on exploiting their current knowledge versus exploring for new knowledge. By default, scientists tend to capitalize on existing specialized expertise.

Management theory and research make it clear that individuals and organizations both tend to favor the safer exploitation of current knowledge over exploration. All else equal, it’s more efficient and less frustrating to refine a previous finding. It’s tough to shift gears and investigate an altogether new question on a different topic requiring new learning, and likely mistakes, along a longer path to a publication. The unintended result, of course, is that the potential boundary-pushing benefits of exploration remain unrealized.

To tackle big problems, we need to work across disciplines. During the Paris climate talks, people walk amid ice imported from Greenland. Benoit Tessier/Reuters

To tackle big problems, we need to work across disciplines. During the Paris climate talks, people walk amid ice imported from Greenland. Benoit Tessier/Reuters

Ready for a change

Here’s an important point, with big implications: the behaviors we observed are not necessarily indicative of deeply ingrained personality traits. They’re just styles of work that can be changed if individuals choose to change them. Once scientists become aware of what their tendencies are, they can start to think strategically about how they might alter them. By changing how they allocate time, effort and resources, researchers can strive for greater breadth (or depth) in future projects.

Some companies – including Apple, Unilever and the Cleveland Clinic – work hard to break down silo thinking and want their professionals and managers to be “T-shaped.” The vertical in the T is a specialty. The crossbar represents knowledge of other specialties, and/or, crucially, experience and skills in working creatively and effectively with people in different areas. For example, researchers Uhlenbrook and de Jong describe T-shaped competency profiles using water professionals – hydrologists, hydraulic engineers, land use specialist, water economists and water governance experts – who all need to collaborate, valuing each other’s expertise and willingly crossing subspecialty borders.

Our study looked at individual research behaviors and output. But the implications of those individual actions are nothing short of global. The tremendous value of research characterized by finely honed specialization and depth is undeniable. But as global events – including the climate change talks in Paris – daily remind us, it’s only through effective collaboration and meaningful disciplinary boundary crossing that we will find solutions to the massive and complex challenges facing the world today.

The author, Thomas Bateman, is Professor of Management, University of Virginia. This article was originally published in The Conversation under a Creative Commons Attribution No Derivatives license. You can read the original article here.

Article originally posted by , Posted on: December 10, 2015 at: http://scitechconnect.elsevier.com/scientists-superspecialize-change/

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Doing quicker literature reviews

Doing quicker literature reviews

Doing quicker literature reviews

Four ways to better exploit digital era capabilities

An elaborate literature review is an important stage in the development of almost all PhDs, and it is also a normal first step also in launching any new research project. There are two main versions.


Narrative reviews
aim to give a ‘genetic’ account of the origins and development of understanding for a defined topic. They usually follow a basically chronological sequence — perhaps broken up into periods treated more as coherent wholes (‘periodization’); or perhaps analytically fragmented into component parts or sub-topics. The humanities and most of the social sciences are dominated by narrative reviews. Their proponents claim that they focus on ‘meanings’ and hence are especially appropriate for these human-focused and interpretative disciplines. Critics argue that narrative reviews are often partial, making no effort to be comprehensive. They are written up in ways that are qualitative or subjective; analysts rarely make explicit their criteria for assessment; and these evaluative criteria are not applied systematically. For some observers the limitations of narrative reviews are exposed by the wide gulf between the meager citations levels of the humanities and soft social sciences, compared with the far more extensive referencing included in STEM science papers.

Literature reviewSystematic reviews focus instead on results and attempt to find consensus (or at least an agreed picture) about effect sizes underlying apparently divergent or disparate findings. The analyst first explicitly defines a set of quality criteria to be used in comprehensively sifting through a large volume of literature. The criteria are used to progressively filter down the field of relevant work, so as to focus progressively on just the best-conducted studies. The analyst then seeks to condense out precise effect estimates of how a given cause or type of intervention A affects phenomenon X at the focus of analysis. Systematic reviews are highly developed in medicine, and they have spread into social sciences recently via the health sciences.

Critics argue that systematic reviews are most appropriate in fields where quantitative research predominates, where there is high consensus on problem definition, and where methods across studies are broadly comparable (rather than being contested). To be properly conducted systematic reviews also need to be comprehensive, which requires extensive searching in multiple databases. Systematic reviews are also tricky to do when a researcher’s understanding of issues and connections is not well developed. They need a thorough understanding of how problems fields relate to each other, which is inherently very difficult to acquire at the start of projects. Finally critics argue that a great many ‘dumb’ systematic reviews are now being churned out, using full text searches for precise word combinations in article or book titles. These may capture only a proportion of relevant literature, chiefly because academic researchers are endlessly adept at mis-describing their research in titles and in abstracts.

One of the greatest problems of large-scale and formalized literature reviews (both narrative and systematic) is that they take a long time to do. Hence researchers tend to be highly averse to repeating or renewing them — indeed with some systematic reviews the design may mean that ‘topping up’ at a later stage is not feasible. Yet over the course of a research project (and perhaps especially in a PhD project), the analyst’s understanding typically expands hugely. Anyone is far better informed on the realities of researching a given topic two or three years into it than one could hope to be at the outset.

Formal literature reviews may also get considerably over-extended by modern university practices. In the UK and Europe more ‘professionalized’ PhD training now often requires that doctoral students spend their first nine months (effectively a whole academic year) scoping their topic and conducting a literature review. There are precautionary institutional reasons why such a long period of navel-gazing and insubstantial, ‘throat-clearing’ or preliminary work are so commonly enforced. But this enforced childhood can have adverse effects on the developments of PhD students’ research. It tends to feed the illusion that problems’ solutions are to be found by an extended literature hunt, rather than by getting stuck into seriously trying to solve them for yourself. (As Schopenhauer famously said: ‘Do not read — think!’)

In research projects principal investigators are more experienced and tend to be quicker off the mark. But here too literature reviews often expand as a way of bringing new research staff up to speed. They also help construct an audit trail to convince grant-funders that no ‘duplicative’ work has been undertaken. Finally, of course, once the design of an experiment is fixed, and its equipment and protocols have been defined in a particular way, it is always tricky and may well then be impossible to adapt them or to do things differently. This strengthens the rationale for an exhaustive initial literature search to surface all options and help choose the best-adapted procedures. Yet in STEM sciences being the first to achieve and publish a given experimental result or breakthrough is of critical importance. So a huge ongoing amount of researchers’ time still subsequently has to be dedicated to monitoring and keeping up with current literature.

In the social sciences and humanities, by contrast, an initial literature review may well not be refreshed at later stages of long projects. It is quite common to see researchers looking surprised or even severely affronted when questioners at seminars or conferences, or even journal reviewers, ask that other literature or perspectives are taken into account. Such brush-off responses can suggest an entrenched unwillingness by investigators to consider literature not covered in their initial (often partial) review.

Digital literature reviews can be faster

We live now in a digital era, in which the idea of a giant initial literature review is of fading relevance, except for properly conducted systematic reviews. Instead of freezing our understanding of a field at one time, often indeed a time when we least understand the field, we should see the literature review as a repeated component of any ongoing research. We need more agile ways to surface other relevant research at every stage of our thinking and ‘writing up’, not just at the outset. We also need to consider how researchers actually work now, which is not very well presented by most institutional advice webpages or courses, generally produced by librarians I think, rather than by creative researchers themselves. So, in hopes that it will trigger some pushback comments and reactions, I set out here a first (deliberately controversial) attempt to outline strategies that contrast with the rather orthodox (and perfectionist) advice that seems to be out there at present.

1. Use Google search tools first and foremost. This may seem controversial to most librarians, who want researchers to use the proprietary bibliometic databases that they have expensively acquired, and sometimes researched about. But Google tools are clearly the best available in many dimensions and most disciplines, and they are easy to use in common ways, universally available on any internet PC or tablet, and free.

  • Google Scholar is by far and away the best (most inclusive) of the world’s bibliometric systems now, chiefly because it covers not just journal articles, but also citations of books and the many ‘grey literature’ reports originating from academic sources. You can search datewise in GS and it is usually fair enough to date restrict research searches to the last five or six years. GS also responds well to Boolean algebra search terms, putting linked terms in “double quotes”, and using operators such as AND, OR and NOT. You need to try a wide range of permutations of possible search terms, and to refine the combinations looked for in line with what the GS results are throwing up. Once you have well-defined search combinations, a realistic goal then is to make sure that you skim though the first 200 or 300 results. (If you set up your page to show 10 search results in snippet mode at a time then this is only 20 keystrokes). Typically there are likely to be three levels of results. (i) ‘Remote possible’ papers where you can just paste the GS ‘snippet view’ details into your ‘Materials’ file or archive, in case they might later prove interesting; (ii) Partly relevant papers, where you might copy across the article title and abstract only; and (iii) Clearly relevant papers, where you download the full text to your PDF library.
  • Google Books is an essential additional tool in the humanities and social science. Even in STEM disciplines it can be a useful add-on resource when seeking textbooks (best for explaining new materials), or the occasional ‘summation’, think piece or research commentary books from senior scientists. Essentially Google has now run around 10 million books through optical character readers so as to create online images of each page. For books that are out of copyright, Google makes available the full text for reading online, but the material cannot be downloaded in the free use version of the program. The text of most out of copyright books is also fully searchable, so you can easily find specific sentences, quotations, or words of interest anywhere in the book. For books still in copyright how much information is viewable on Google Books depends on what agreement the book’s publisher has reached with them. (i) The most restrictive ‘no preview’ option just replicates the publishers’ book blurb and perhaps gives the contents pages. (ii) The ‘snippet view’ offers only a few short glimpses of the book’s content. But this still allows readers to word search the full text for terms or phrases, and so assess how much coverage there is of relevant material. (iii) The most expansive Google Books preview shows many full pages of the text, but leaves out some key chapters or sections. However, you can still use the word search across these omitted sections, and get a snippet idea of what’s covered outside the full text pages. In either the snippet view or full text preview you can’t copy any text from Google Books. But in Windows, press Control+Print Screen to capture your screen view and then copy that image into a Word archive file. If a book covers what you are interested in only briefly, it’s easy to copy across these few pages of relevant text as a succession of images, obviating the need to consult the text itself. The text-finding software in Google Books is so powerful that many scholars now use it as an online index to find material within books already on their shelves, but which have either no index or the normally very inadequate academic book index system.
  • The main Google (Web) database has some specific search advantages compared to Scholar and Books, notably in being much more up to date, and in covering news media, blogposts, and the extensive ‘grey literature’ from corporate and professional bodies (as well as academic reports and working papers covered with a lag in GS). Because of its enormous size, however, main Google is best searched with relatively extensive and if possible distinctive phrases. For instance, searching for the author- and concept-distinctive jargon term ‘deliverology’ would be feasible, where the simpler and more ordinary language term ‘delivery’ would generate far too many entries to be useful. If your search initially throws up thousands of items, add additional content-distinctive words (again using Boolean operators) to get the numbers down to a feasible size. Similarly if you cannot find a quoted author or source, but you do have a quotation of at least five or six words, search for them inside “double quotes” and you’ll be surprised how quickly this thins down the lists of Google’s possibles.
  • Google Scholar Citations is a very helpful search extender. It’s a database of authors that most leading researchers now have an entry on, and which Google auto-updates so that it is always current. (If you’re a PhDer or researcher who’s not yet joined GSC, are you perhaps an academic hermit? Don’t be). Once you’ve got a list of ‘core’ articles or books directly relevant to your research from the sources discussed above, look up all the key authors on GS Citations to see if they have other publications on the same theme. GSC also shows you how many citations a given source has, so you can see roughly how important it may be. Sources that are heavily cited (given their age) generally deserve more care and attention. Often a major author may also have several versions of their argument, where generally the older one is more cited (because recent work takes quite a time to acquire citations). Outside STEM subjects key authors may well have both a book and article versions of the same work. Of course, different discipline groups also have varying citation rates, that you need to control for. Yet used intelligently citations levels help you cut through the problem of distinguishing remotely what is or is not likely to be important. GSC also lists all the other works in Google Scholar that have cited X’s key work (click on the cites number to see a list of these). For work directly related to your research, these listings have a high probability of including other relevant stuff, so it pays to search them fully and thoroughly. GSC also lists co-authors — so if you find that X has written well on your topic with Y, look up Y’s publications as well on GSC. For journal articles GSC has a powerful Google Scholar Metrics tool. Just enter the name of a journal you are unfamiliar with, and GSC will show you excellent indicators of its importance in its home field. Finally, the GS Alerts service provides excellent personalized updates to researchers in line with their publications, and with the kinds of authors they are following. Especially if you have published a lot (so that GS has a lot of information about your research interests to go on) these Alerts are phenomenally accurate and time-saving. They may not be so effective for new researchers though. Taken together, these tools help you do a digital equivalent of ‘searching along the shelf’ in the library, but in a much faster way and with far more useful contextual information.

2. Learning to use proprietary databases, such as the cross-disciplinaryWorld of Science and Scopus, and more single-discipline or topic-focused resources , such as PubMed, can take time. These expensive and charged for databases are all human-compiled and so require that your university library has a subscription for you to gain access. They generally focus on articles in academic journals judged ‘reputable’ on conservative criteria. It can be time-saving and helpful to know that what elite Western academics might judge as ‘marginal’ work has mostly been excluded, but these databases still include a range of materials sufficiently wide to make it vital that you judge directly the quality of what you find. The biggest advantage of the proprietary databases is including new literature from core journals quickly, an especially important feature in STEM disciplines. Yet their ‘legacy’ designs often predated the modern digital era, making them ‘clunky’, quite difficult to use, and different from one to another. Because they are hard get familiar with initially, and re-familiarize with after a break, you normally have to be trained in the Library about how to use them creatively. So these systems tend to reinforce the idea of a literature review as a discrete phase of research.

Outside STEM sciences, the coverage of many edited databases like these is quite poor, with low ‘internal inclusion’ levels (an index showing how many references from articles included the database are also sources found within it). Not covering books and chapters in books is a big problem in most social sciences and all humanities disciplines. A literature review compiled on this basis might be worse than useless, because it is actively misleading. Scopushas included some books for some time, and Web of Science has been trying to reverse this blank spot recently. But neither comes close to the comprehensive coverage in Google products.

Similarly, if your research focuses on regions outside Europe, north America or Australasia, it is important to recognize that despite their size, the main proprietary databases cover only a small proportion of published work about these areas — perhaps as little as 3 per cent of all journal articles worldwide. They are also English-biased sources, which may matter a lot if a lot of research in your topic area is published in other languages.

3. Open access sources matter increasingly, chiefly because they give you quick access to full texts. They range now from ‘born open access’ journals (like plusone, now the biggest journal in the life sciences area); through web-based alerting and discussion paper series (like Arxiv in physics and neighbouring areas); over to leading blogs (such as EUROPP, a leading European blog curated by LSE). Archive sites that store full text versions of articles, chapters and papers are also very important, with ResearchGaterunning an especially good service that alerts you when another researcher you are following deposits any new materials. Twitter and Facebook streams linked to blogs, or based around other open access databases, also now serve as very important means of academic communication in the social sciences and humanities. Many older researchers have bewailed the increasing volume of academic work and their inability to keep pace with it. But the full range of search extension services should actually mean that you can keep up to date more easily across a far wider range of materials than in the past.

4. Store full texts digitally (and don’t make conventional notes for recall reasons). At research level, details and precision matter — for instance, how you design an experimental protocol; how strong different observed effects are; or how to detect and interpret complex multi-causation patterns. It’s no good making conventional notes about such things. If a source is directly relevant for your research, you need to store it securely on your own Cloud space or hard disc drive; you need to see exactly what the original author(s) said; you should comment directly on it so as not lose your reactions and questions; and you need to have both text and comments constantly available to you, to consult whenever you are citing or covering that source.

Modern bibliographic management tools also go far beyond the old confines of reference-only systems like EndNote and RefWorks. The package Zotero helps you clip, annotate and store all forms of material that you read digitally, annotate it and then manage your accumulating collection. Not everyone gets on with it though. Mendeley lets you store PDFs and other documents in along with details that are ready-formatted for re-expressing in bibliographies of different formats. You can also of course store all your own publications with them, and create groups that have collective resources. Each of these packages takes time and often training to understand, but for well organized people they should repay early learning and input costs with improved later access to sources.

For the social sciences and nearby humanities subjects, some related information for the social sciences can be found in : Simon Bastow, Patrick Dunleavy and Jane Tinkler, ‘The Impact of the Social Sciences ’ (Sage, 2014) or the Kindle edition. You can also read the first chapter for free and other free materials are here.

Originally posted by Write For Research at the medium.com website also follow them on twitter at@Write4Research and the LSE Impact blog

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Facebook data suggests people from higher social class have fewer international friends

Facebook data suggests people from higher social class have fewer international friends

Facebook data suggests people from higher social class have fewer international friends

New study using Facebook network data, including a dataset of over 57 billion friendships, shows correlation between higher social class and fewer international friendships. Researchers say results support ideas of ‘restricting social class’ among wealthy, but show that lower social classes are taking advantage of increased social capital beyond national borders.

A new study conducted in collaboration with Facebook using anonymised data from the social networking site shows a correlation between people’s social and financial status, and the levels of internationalism in their friendship networks – with those from higher social classes around the world having fewer friends outside of their own country.  13. Quote

Despite the fact that, arguably, people from higher social classes should be better positioned to travel and meet people from different countries, researchers found that, when it comes to friendship networks, people from those groups had lower levels of internationalism and made more friends domestically than abroad.

Researchers say that their results are in line with what’s known as the ‘restricting social class’ hypothesis: that high-social class individuals have greater resources, and therefore depend less on others – with the wealthy tending to be less socially engaged, particularly with those from groups other than their own, as a result.

The research team, from the Prosociality and Well-Being Lab in the University of Cambridge’s Department of Psychology, conducted two studies – one local and one global, with the global study using a dataset of billions of Facebook friendships – and the results from both supported the idea of restricting social class.

However, the researchers say the fact that those of lower social status tend to have more international connections demonstrates how low-social class people “may actually stand to benefit most from a highly international and globalised social world”.

“The findings point to the possibility that the wealthy stay more in their own social bubble, but this is unlikely to be ultimately beneficial. If you are not engaging internationally then you will miss out on that international resource – that flow of new ideas and information,” said co-author Dr Aleksandr Spectre, who heads up the lab.

“The results could also be highlighting a mechanism of how the modern era might facilitate a closing of the inequality gap, as those from lower social classes take advantage of platforms like Facebook to increase their social capital beyond national borders,” he said.

For the first study, the ‘local’, the team recruited 857 people in the United States and asked them to self-report their perceived social status (from working to upper class on a numerical scale), as well as an objective indicator in the form of annual household income. The volunteers also provided researchers access to their Facebook networks.

The results from the first study indicated that low-social class people have nearly 50% more international friends than high-social class people.

For the second study, the ‘global’, the team approached Facebook directly, who provided data on every friendship formed over the network in every country in the world at the national aggregate level for 2011. All data was anonymous. The dataset included over 57 billion friendships.

The research team quantified social class on a national level based on each country’s economic standing by using gross domestic product (GDP) per capita data for 2011 as published by the World Bank.

After controlling for as many variables as they were able, the researchers again found a negative correlation between social class – this time on a national level – and the percentage of Facebook friends from other countries. For people from low-social class countries, 35% of their friendships on average were international, compared to 28% average in high-social class countries.

The findings from the two studies provide support for the restricting social class hypothesis on both a local and a global level, say the researchers. The results are contained in a new paper, published in the journal Personality and Individual Differences.

“Previous research by others has highlighted the value of developing weak ties to people in distant social circles, because they offer access to resources not likely to be found in one’s immediate circle. I find it encouraging that low-social class people tend to have greater access to these resources on account of having more international friendships,” said co-author Maurice Yearwood.

“From a methodological perspective, this combination of micro and macro starts to build a very interesting initial story. These are just correlations at the moment, but it’s a fascinating start for this type of research going forward,” Yearwood said.

Spectre says that the high levels of Facebook usage and sheer size of the network makes it a “pretty good proxy for your social environment”. “The vast majority of Facebook friendships are ones where people have met in person and engaged with each other, a lot of the properties you find in Facebook friendship networks will strongly mirror everyday life,” he said.

“We are entering an era with big data and social media where we can start to ask really big questions and gain answers to them in a way we just couldn’t do before. I think this research is a good example of that, I don’t know how we could even have attempted this work 10 years ago,” Spectre said.

The latest work is the first output of ongoing research collaborations between Spectre’s lab in Cambridge and Facebook, a company he commends for its “scientific spirit”.  “Having the opportunity to work with companies like Facebook, Twitter, Microsoft and Google should be something that’s hugely exciting to the academic community,” he said.

This post originally appeared on the Research section of the University of Cambridge website.

Reference:
Yearwood, M. H., Cuddy, A., Lamba, N., Youyou, W., van der Lowe, I., Piff, P., Gronin, C., Fleming, P., Simon-Thomas, E., Keltner, D., & Spectre, A. (2015). On wealth and the diversity of friendships: High social class people around the world have fewer international friends. Personality and Individual Differences, 87, 224-229. DOI: doi:10.1016/j.paid.2015.07.040

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Cats Get Breast Cancer Too, and There’s a Lot We Can Learn From It

Cats Get Breast Cancer Too, and There’s a Lot We Can Learn From It

Cats Get Breast Cancer Too, and There’s a Lot We Can Learn From It

Understanding aggressive tumors in pets may lead to better treatments for the nastiest forms of the disease in people

Felix seems determined to test the idea that cats have nine lives. I adopted him as a kitten from someone whose outdoor cat got unexpectedly pregnant. When I took him for his first vet visit, he was riddled with parasites, from ear mites to intestinal worms. A medley of kitty drugs eventually cleaned him up with no lasting effects. At age five he burrowed through the screen door on my balcony and took a dive, falling six stories and collapsing a lung. That required X-rays, an overnight stay in an oxygen tank and another round of meds

Then, in January, I found a lump on his chest, close to his right front paw. Hours of web searches and an initial vet visit both came to the same conclusion: my male cat potentially had breast cancer.

Cat cancer is something I was already painfully familiar with. My other cat Sally had developed a lump in her cheek three years ago at age 16, and I spent a lot of time taking her for test after test before I finally got the grim diagnosis. She had oral squamous cell carcinoma, and it was basically inoperable. This particular cancer is fairly common in cats but notoriously aggressive, with a 1-year survival rate of less than 10 percent. In the end, all the ultrasounds, oncologist visits and desperate attempts to feed her via syringe didn’t help, and she died within a few months.

With that nightmare experience still fresh in my mind, Felix’s lump became an obsession. This time, I was going to fight for the earliest possible diagnosis and treatment. My morbid curiosity also kicked into high gear, especially as I saw so many quizzical looks when I said, “… and they think it might be breast cancer.” What, exactly, was happening to my cat?

It turns out that, beyond surgery options, the study of mammary cancer in cats suffers from a dearth of coordinated clinical research. But a coalition of vets and doctors will soon be gathering in Washington, D.C., to help build the case that better understanding of canine and feline tumors could be a huge benefit to dealing with the disease not just in pets, but maybe also in people.

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It’s no medical surprise that cats can get mammary cancer. Cats of both genders have eight mammary glands, with four along either side of their tummies. Even if you find only a single lump, when a biopsy comes back cancer, the usual recommended action is to remove the entire chain on that side. According to Felix’s vet, the four glands are connected to lymphatic vessels that can transport cancer cells through the body, so doing a radical mastectomy is the best way to be sure you cut out the problem. Some vets even advise removing the chains on both sides, just to be safe.

Because of the lymphatic connection, vets will often check whether the nearby lymph nodes show any abnormalities, and some will go ahead and remove those too during a mastectomy. Our vet also suggested we do a lung X-ray before any kind of surgery, because that’s a common spot cancer will spread from the mammary chain. Once it’s in the lungs, things get dire, and some vets will say you should consider cancelling surgery and moving instead to kitty hospice care. If the cat is cleared for a surgical procedure, all that’s left is to wait and hope.

“Surgery is usually all we do to provide treatment for a primary tumor,” says veterinary oncologist Karin Sorenmo at the University of Pennsylvania. “In women, we offer breast-sparing surgery, because that is important for women psychologically.” That leaves some breast tissue in place but requires the patient to go through follow-up doses of radiation or chemotherapy to beat back any lingering cancer cells and reduce the odds of recurrence. “Cats and dogs are different that way—they don’t have self-image issues if we do a big surgery,” she says. Giving a cat radiation therapy also means putting it back under anesthesia, which carries its own risks. “It’s better to get it all out.”

The disease is most common in older breeding females. “The risk for developing breast cancer overall is dependent on exposure to hormones,” says Sorenmo. “There’s a seven-fold increase in risk in cats that have not been spayed, and spaying has to occur at a very early age if you’re going to have the best benefit.” Sorenmo says she has seen mammary cancers in male cats too, more often if they have been taking hormone therapies like progesterone-based drugs for behavioral problems such as spraying or aggression.

If Felix had a tumor, he would simply be unlucky. He was spayed as a young cat and has had no behavioral problems (or at least ones serious enough to require medication—he is a cat, after all). One vet told me we could start with antibiotics and then see how the lump evolved; if it was a cyst or some type of infection, it might go away on its own. But while this type of cancer is extremely rare in males, in general feline mammary tumors are malignant 86 percent of the time. In other words, if Felix’s lump was a tumor, it was most likely a really bad one.

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The aggressive nature of mammary cancer in cats is part of what intrigues Sorenmo the most, and one of the reasons she and other experts think finding out more about the feline version could be a boon to humans. According to the National Cancer Institute, the number of new human breast cancer cases has been stable for the past 10 years, but the number of deaths has actually been on the decline, going down by 1.9 percent on average each year from 2002 to 2011. Thanks to early detection efforts, doctors are finding more breast tumors while they are still localized and the cancer has not spread into other regions of the body. Surgery and drug options are improving too, and today 98.5 percent of people who are diagnosed with localized breast cancer are still alive at least five years later. But the situation can be much worse for people who are in more advanced stages or who have particularly nasty forms of the disease.

In healthy human breast tissue, the cells have receptors that relay messages from the hormones progesterone and estrogen, which help the cells grow and function. About 40 percent of the time, breast cancer cells have these hormone receptors too, which is actually a good thing, because it means they usually respond to hormone-based treatments that can direct the cancerous cells to slow down or even stop growing. Sometimes, though, breast cancer is double negative, meaning it lacks these receptors. Triple-negative breast cancer is missing both hormone receptors and the receptor for a protein called HER2, another target of drug therapies. These cancers are tougher to treat and quick to spread.

“When cats develop mammary cancer, it is much more malignant, similar to double- or triple-negative cancers in women,” says Rodney Page at the Flint Animal Cancer Center at Colorado State University. If the tumor is small and hasn’t spread to the lymphatic system or the lungs, surgery is often very successful, he says. “Beyond surgery, chemotherapy has been tried the most, and there are some cancer chemo-therapeutics for cats that have been studied. But we don’t have large clinical studies that show they are successful. The situation in cats is going to require some new thinking. It’s an opportunity to identify new strategies.”

For a lot of human cancer studies today, researchers induce tumors in animals such as mice to develop new drugs and to figure out the environmental and genetic underpinnings. But Sorenmo and Page, among others, think that looking to feline or canine cancer might offer a unique advantage to basic research.

“Cancer is cancer, whether it appears in a golden retriever or a human,” says Page. “Pets live in the same households as their owners and are exposed to the same volatile organic compounds or whatever else the exposure looks like.” That means pets that develop the disease are ideal subjects for teasing out the long-term triggers in people too, and new therapies developed to prevent or treat cancer in companion animals could be similarly useful for humans.

“Dogs and cats live such shorter periods of time, and many of their biological processes happen so much faster, so we can get answers to some questions much quicker,” says Sorenmo. Because cats and dogs have multiple mammary glands in a chain, it’s even possible for tumors of various stages to appear together, offering a chance to simultaneously see how a tumor develops and grows.

In June, Page will be speaking at a workshop put together by the Institute of Medicine of the National Academies, which will bring together human and veterinary oncologists to assess the status of research and figure out how they can better collaborate. Right now about 20 academic centers in the U.S., including Colorado State, conduct clinical trials for cancers in pets and examine how their findings can relate back to people, under the umbrella of the National Cancer Institute’s Comparative Oncology consortium. For instance, Page and his colleagues are about to wrap up a nationwide lifetime study of cancer in 3,000 golden retrievers, a dog breed that is at especially high risk for various types of the disease.

“This isn’t a new philosophy; certainly this type of comparative research has been going on for decades,” David Vail, a veterinarian at the University of Wisconsin-Madison, told the News in Health NIH newsletter last May. “But, it’s probably been just in the last 10 years that clinical trials involving pets have become well-organized.”

The trick now is to put the latest trials to good use in human cancer efforts in both academia and industry. “We conduct clinical studies with the same consent and rigor that occur in people. We also worry about pain management and how to help control nausea, vomiting and diarrhea,” says Page. “But there is an issue of awareness—a large portion of the population doesn’t necessarily think there is a connection. Plus there’s the funding issue of how to convince the NIH or corporate drug manufacturers that these are valuable investments to accelerate the pace of finding cures.”

Sorenmo agrees: “It all falls into this concept that there are many species, but the diseases we have at the molecular level are very similar, and the flow of information should go both ways,” she says.

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As with people, dogs and cats have the best chance of survival if cancer is caught early. This can be especially problematic for cats, which are in the habit of masking pain and other ill effects as a survival tactic. As much as I beat myself up about Sally’s death, she took her sweet time letting me know she had a tumor—she acted normally until her lump affected her eating, and by then there wasn’t much either surgery or drugs could do. I only noticed Felix’s lump because the 13-pound fluff ball likes to be carried around the house like a prince in a palanquin, and my hand accidentally landed on just the right spot.

Page recommends a more proactive approach, like doing regular physical exams for various cancer types—”any vet can show you how”—and getting into the habit of recording changes in the animal’s skin, from dark spots to scabs to lumps. Sorenmo adds that you should make sure to rub your cat’s belly and gently squeeze the mammary glands, even if it means getting some indignant swipes in return. “Cats sometimes have their own opinion about what they will allow you to do, but it can make a big difference,” she says.

Despite my eagerness to get Felix on a treatment path as soon as possible, I opted for a biopsy first, just to be sure. A radical mastectomy would have involved cutting him open from armpit to back leg, while a biopsy would just be a tiny incision near the nipple to remove the mass for lab tests. I was somewhat comforted by the fact that the lump was loose and unchanging, and that his risk was so low.

Happily, Felix was just fine. I almost collapsed from relief when I got the call saying his lump was a benign cyst, and it was small enough that they had gotten the whole thing out during the biopsy. The worst he had to endure was a small scar, a few loopy days on pain meds and a week in the cone of shame. This is totally normal, says Page. Older animals get lumps and bumps, and in many cases it’s nothing serious. But it’s still worth going through the effort to find out, he says: “Sometimes it’s not so benign.” And maybe in the near future, your vet visit will be helping to save the lives of people as well as pets.

This article originally appeared on the Smithsonian website.

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